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A Guide to Glucosamine Products

Synflex ® - America’s first choice in liquid Glucosamine!

Glucosamine Products, before you buy:

When your pain relief and health is at stake, you need to know how to choose between competing glucosamine products and see through the marketing hype. There are six factors that you need to take into your decision before purchasing glucosamine products. These are:

  • Amount of glucosamine per daily dose
  • Type of glucosamine
  • Quality of Ingredients
  • Delivery System
  • Synergistic Ingredients
  • Price Per Day

  • It is very important to compare price per day and not price per glucosamine product, as many companies try to fool you by providing 60 capsules or 32 oz. and not telling you until after you purchased that you must use 6 capsules or 2 oz. per day. Be careful to always compare price per day.

Did you know that nutritional supplements like glucosamine are usually absorbed faster and become bioavailable faster in liquid form than in pill form? In addition, with pills you run the risks that binders and fillers in the pills, coatings on the outside of the pills, or the highly compressed form of the pill will cause the glucosamine in the pill to be less absorbable and less bioavailable than glucosamine in liquid form and, as a result, pass through your digestive system without having the intended beneficial effect on your osteoarthritis.

Comments about our rating system
Clinical studies have indicated that when glucosamine is delivered into your body in liquid form, it is absorbed more quickly than in pill or capsule form. For that reason, a liquid formula provides faster relief.

For that reason, we have given two ratings for capsule products since the comparison is between "apples and oranges." The capsule or pill ratings stand based on our evaluation of them in that form.

There are websites being operated on the internet that purport to be neutral in their product evaluations. However, most fail to alert consumers that in fact, they are promoting their own products without fully disclosing their interest. It is our feeling that this is unfair to the consumer. For that reason, we want to advise you that this evaluation is being provided by Synflex America, Inc., the makers of Syn-flex®. We have had years of experience in this industry and our interest is in providing you with information that we hope will be useful in making an informed decision about the product you select. We also suggest that you take a careful look at product comparisons on other websites and try to ascertain who is funding each such website. If someone is failing to disclose their identity on an endorsement, then they may be willing to hide other information important to your purchasing decision.

First, let's review the leading liquid glucosamine formulas:

Synflex ® 1500
Synflex ® Original Formula
Glucosamine Information:
Liquid Glucosamine Formula Synflex
Doctor Recommended

Liquid Glucosamine Formyla Synflex
Doctor and Veterinarian Recommended

Amount per daily dose: 1500 mg 1250 mg
Type both glucosamine Sulfate and glucosamine HCL both glucosamine Sulfate and glucosamine HCL
Quality: Pharmaceutical Quality
Pharmaceutical Quality
Delivery System: Liquid Liquid
Synergistic Ingredients:

White Willow Bark for greater anti-inflammatory impact; Chrondroitin Sulfate, Boswellin, Yucca Powder, Manganese, Ascorbate, Bromelain, Vitamin C, Omega 3 Fatty Acids, Omega 6 Fatty Acid, Vitamin A, Vitamin E.

Syn-flex ® 1500 is not recommended for pets. Use only the regular formula Syn-flex ® for pets.

Chondroitin Sulfate, Boswellin, Yucca Powder, Manganese Ascorbate, Bromelain, Vitamin C, Omega 3 Fatty Acid, Omega 6 Fatty Acid, Vitamin A, Vitamin E
Price per day:
Rating Rationale: More glucosamine to an already successful formula and delivered in liquid form to ensure maximum absorption. The 11 synergistic ingredients that have all been shown to aid in the fight against arthritis make this a great product. Plus great new Orange flavor! A good amount of both forms of glucosamine delivered by liquid will ensure maximum absorption. The high quality glucosamine, and 10 synergistic ingredients that have all been shown to aid in the fight against arthritis combine to make a very good product.


Glucosamine Information:

Amount per daily dose: 100 mg 2100 mg
Quality: not stated pharmaceutical-grade
Delivery System: Liquid Liquid
Type glucosamine Sulfate glucosamine HCL
Synergistic Ingredients: 6 calories, 1.4 grams of Carbohydrate, 8 mg. of Vitamin C, 300 mg. of Mucopolysaccharides, 100 mg. of glucosamine Potassium Sulfate, and 100 mg. of MSM (Methylsulfonylmethane). Other ingredients include Filtered Water, Fructose, Natural Flavors, Citric Acid, Red Cabbage Extract (for color), Sodium Benzoate (Preserves Freshness)

600 mg of Chondroitin Sulfate, 600 mg of MSM, 1.9 mg of Manganese, 500mg of Vitamin C, 20 mg of Yucca, 15 mg of Boswellic Acid

Price per day:
$1.06 - $2.12
$1.06 - $2.12
Rating Rationale: A low amount of glucosamine, unknown quality of ingredients, an alternate system of chondroitin delivery. The product has very little in it besides fruit flavoring. The thing this product has going for it is that it is in liquid form. A good mix of ingredients with a good supply of glucosamine. The glucosamine is glucosamine HCL. It has MSM; there are very few studies of the effects of MSM on humans. Those who advocate using MSM to relieve arthritis pain say that you should take from 1000 mg to 6000 mg per day to realize its benefits. It also has a little Manganese, and 833% of the RDA of Vitamin C, which may cause a severely upset stomach for many. The very high price will rule it out for most budgets, but if you can afford it, it may give you some relief seeing that it is in liquid form.


Joint Juice™
Cosamin DS™ *
Glucosamine Information:

Amount per daily dose: 1500mg 1000 mg
Quality: not stated not stated
Delivery System: Liquid pill
Type not stated glucosamine HCI
Synergistic Ingredients: 1500 milligrams of glucosamine and 60 milligrams of vitamin C, with real fruit juice. 800 mg Chondroitin Sulfate, 20mg Manganese, 132 mg Ascorbate
Price per day:
$.81 (varies slightly depending on retail outlet)
Rating Rationale: A good supply of glucosamine and vitamin C, however, besides those, there is very little in this product except fruit juice. It is an expensive novelty drink that provides an adequate supply of liquid glucosamine but does not contain any additional anti-inflammatory or pain-relieving ingredients or ingredients having any synergistic beneficial effects. A good amount of glucosamine, it is glucosamine HCL. There is a good amount of Chondroitin, but 750% of the RDA of Manganese, which can be harmful and cause a high intensity of basal ganglia. In pill form, the glucosamine HCL and chondroitin sulfate may not be absorbed very well and provide less than optimal pain relief


* The Capsule Formulas
Reminder: glucosamine provided in liquid form is absorbed more quickly, much more fully, and provides greater and longer lasting relief.

Due to this, we have given two ratings for the capsule products since we need to be comparing apples with apples. The overall rating is a rating that is compared to all products. The capsule rating is a rating as it stands among only products which provide glucosamine in pill form.

A note on MSM: There are very few studies of the effect of MSM on humans but some do show that MSM reduces inflammation and pain if taken in an adequate daily dosage. The human studies known to us are by Dr. Lawrence at UCLA who gave the patients 2250 mg per day (750 mg 3 times per day)and by P.R. Usha who gave the patients 1500 mg (500 mg 3 times per day). If you are going to take MSM, it appears that large dosages may be necessary to experience any pain-reducing benefits it may have.

The below capsule products are not recommended because they:

  • Failed independent testing
  • Contain a mixture of herbs not known to be safe
  • Put consumers at risk for lead/mercury contamination
  • Contain unproved substances

The below products are not highly recommended.

Capsule Products to Avoid:

  • glucosamine Plus
  • Joint Care
  • Pain Free
  • Joint Fuel
  • Joint Rescue
  • Osteo-Joint
  • Can-Do

The Creams

There is growing evidence that glucosamine can actually be absorbed through the skin. For that reason, the makers of Syn-flex® also make available a topical analgesic which contains glucosamine.

Syn-flex® Power+Plus.

In summary, we recommend products that contain pharmaceutical level, high quality, liquid glucosamine sulfate or a mixture of both glucosamine sulfate and glucosamine HCL. The best products are also combined with ingredients that work synergistically with glucosamine to help rebuild cartilage, ease pain, reduce inflammation, and increase mobility. These include:

  • White Willow Bark
  • Chondroitin Sulfate
  • Boswellin
  • Yucca Powder
  • Manganese Ascorbate
  • Bromelain
  • Vitamin C
  • Omega 3 Fatty Acid
  • Omega 6 Fatty Acid
  • Vitamin A
  • Vitamin E

While the majority of research to date has been done on pill products, liquid products provide greater absorption and greater availability meaning greater pain relief for osteoarthritis sufferers. Overall, there are a great many products that can assist, and it is wise to research and do your homework on what would be best for you.

As far as capsule formulas are concerned, we recommend Osteo-Bi-Flex and Cosamin DS, however, we recommend that first you try a liquid glucosamine product with the qualities described above for the reasons stated above.

As noted throughout this page, Synflex America, Inc. provides this information. Synflex America, Inc. believes that good quality liquid glucosamine products are more beneficial to osteoarthritis sufferers than are glucosamine pill, powders, or tablets. Among the liquid glucosamine products, Synflex America believes that its product, Syn-flex® is the best for the reasons stated above. You, of course, must exercise your own judgment about which product is the most beneficial at a reasonable cost.

For more information on Syn-flex®, you may visit